Heart disease is the #1 global killer and while cholesterol's precise role is debated, most agree LDL cholesterol - a.k.a. "bad cholesterol" - plays at least some role.

Which is why people spend ~$20 billion/year on statin drugs to lower LDL (note: statins are also hotly debated).

Welp…Eli Lilly may have just radically changed the landscape.

This week they published clinical data of a gene therapy called VERVE-102 that reduced LDL up to 62% after a single dose. Even wilder? The effect held for eighteen months.

VERVE-102 isn't a drug - it's a means of editing your genome to permanently turn off the liver gene responsible for high LDL levels.

And again, it's one. single. shot.

Some think this foretells the end of most heart disease - an astonishing possibility. Others warn about caveats to the study (e.g., small trial, no comparison group).

Either way, this is likely to change the world in a big way.

Gas prices are gassy right now (too high).

As a result, many folks are seeking out which stations have the cheapest gas (this often entails driving more miles to save on driving miles – ironic!).

But guess what: the day of the week matters far more than the brand or station.

GasBuddy ran the numbers on all 50 states.

Sunday is the cheapest in 41 of them. Monday is next-cheapest. Wednesday through Friday is the most expensive.

Hump Day ≠ Pump Day

1. Has screaming for ice cream ever worked?

2. One of your keys probably works on some other lock in the world.

3. You have ten minutes before feeling effects of a meteor impact if you're standing at the opposite end of Earth.

4. It's often not what we read that determines our opinions, but the order in which we read it.

5. Technically, people read more in the smartphone era than they did before.